Structure of PDB 6bux Chain A

Receptor sequence
>6buxA (length=190) Species: 9606 (Homo sapiens) [Search protein sequence]
RHSMDPATFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVKLAQRRGFLA
NQAKHKHGFLEGRHAALCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQ
EMAKFISKNKHVSLCIKTARIYDDKGRAAEGLRTLAEAGAKISIMTYSEF
KHCWDTFVDHQGAPFQPWDGLDEHSQDLSGRLRAILQNQE
3D structure
PDB6bux Crystal structure of the catalytic domain of HIV-1 restriction factor APOBEC3G in complex with ssDNA.
ChainA
Resolution1.856 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.4.38: single-stranded DNA cytosine deaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A W211 R213 H216 T218 N244 A246 K247 H257 W285 S286 Y315 D316 D317 K318 W18 R20 H23 T25 N51 A53 K54 H64 W92 S93 Y122 D123 D124 K125 PDBbind-CN: Kd=55uM
BS02 ZN A H257 C288 C291 H64 C95 C98
Gene Ontology
Molecular Function
GO:0003824 catalytic activity

View graph for
Molecular Function
External links
PDB RCSB:6bux, PDBe:6bux, PDBj:6bux
PDBsum6bux
PubMed29941968
UniProtQ9HC16|ABC3G_HUMAN DNA dC->dU-editing enzyme APOBEC-3G (Gene Name=APOBEC3G)

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