Structure of PDB 6bu0 Chain A

Receptor sequence
>6bu0A (length=123) Species: 9606 (Homo sapiens) [Search protein sequence]
GGAVKLSISYRNGTLFIMVMHIKDLVTEDGADPNPYVKTYLLPDNHKTSK
RKTKISRKTRNPTFNEMLVYSGYSKETLRQRELQLSVLSAESLRGNFFLG
GVTLPLKDFNLSKETVKWYQLTA
3D structure
PDB6bu0 Molecular Basis for Membrane Recruitment by the PX and C2 Domains of Class II Phosphoinositide 3-Kinase-C2 alpha.
ChainA
Resolution2.427 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.137: phosphatidylinositol 3-kinase.
2.7.1.153: phosphatidylinositol-4,5-bisphosphate 3-kinase.
2.7.1.154: phosphatidylinositol-4-phosphate 3-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IHP A Y1595 K1597 Y1599 K1609 G1654 N1655 Y36 K38 Y40 K50 G95 N96
External links
PDB RCSB:6bu0, PDBe:6bu0, PDBj:6bu0
PDBsum6bu0
PubMed30293811
UniProtO00443|P3C2A_HUMAN Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (Gene Name=PIK3C2A)

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