Structure of PDB 6bto Chain A

Receptor sequence
>6btoA (length=201) Species: 9606 (Homo sapiens) [Search protein sequence]
AATSRPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERT
DEDSYIVFTYRPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVG
FWHEHTRPDRDRHVSIVRENIQPGQEYNFLKMEPQEVESLGETYDFDSIM
HYARNTFSRGIFLDTIVPKYEVNGVKPPIGQRTRLSKGDIAQARKLYKCP
A
3D structure
PDB6bto Reverse Hydroxamate Inhibitors of Bone Morphogenetic Protein 1.
ChainA
Resolution2.05 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H93 E94 H97 H103 Y152
Catalytic site (residue number reindexed from 1) H93 E94 H97 H103 Y152
Enzyme Commision number 3.4.24.19: procollagen C-endopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H93 H97 H103 H93 H97 H103
BS02 ZN A D145 D189 D145 D189
BS03 E8P A R8 C66 S67 Y68 V69 H93 E94 H97 W102 H103 Y127 R8 C66 S67 Y68 V69 H93 E94 H97 W102 H103 Y127 PDBbind-CN: -logKd/Ki=5.00,IC50>10000nM
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6bto, PDBe:6bto, PDBj:6bto
PDBsum6bto
PubMed30034610
UniProtP13497|BMP1_HUMAN Bone morphogenetic protein 1 (Gene Name=BMP1)

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