Structure of PDB 6btn Chain A

Receptor sequence
>6btnA (length=201) Species: 9606 (Homo sapiens) [Search protein sequence]
AATSRPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERT
DEDSYIVFTYRPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVG
FWHEHTRPDRDRHVSIVRENIQPGQEYNFLKMEPQEVESLGETYDFDSIM
HYARNTFSRGIFLDTIVPKYEVNGVKPPIGQRTRLSKGDIAQARKLYKCP
A
3D structure
PDB6btn Reverse Hydroxamate Inhibitors of Bone Morphogenetic Protein 1.
ChainA
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.19: procollagen C-endopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H93 H97 H103 H93 H97 H103
BS02 ZN A A1 E104 Q192 A1 E104 Q192
BS03 E8M A N84 I90 H93 E94 H97 H103 Y152 T156 F157 G180 R182 N84 I90 H93 E94 H97 H103 Y152 T156 F157 G180 R182
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:6btn, PDBe:6btn, PDBj:6btn
PDBsum6btn
PubMed30034610
UniProtP13497|BMP1_HUMAN Bone morphogenetic protein 1 (Gene Name=BMP1)

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