Structure of PDB 6bt2 Chain A

Receptor sequence
>6bt2A (length=270) Species: 9606 (Homo sapiens) [Search protein sequence]
RPPRFQRDFVDLRPPIRVMQWNILAQALGVEALKWEERKCLILEEILAYQ
PDILCLQEVDHYFDTFQPLLSRLGYQGTFFPKPWSPCLDVEHNNGPDGCA
LFFLQNRFKLVNSANIRLTAMTLKTNQVAIAQTLECKESGRQFCIAVTHL
KARTGWERFRSAQGCDLLQNLQNITQGAKIPLIVCGDFNAEPTEEVYKHF
ASSSLNLNSAYKLLSADGQSEPPYTTWRHTLDYIWYSKHALNVRSALDLL
TPSFNYPSDHLSLVCDFSFT
3D structure
PDB6bt2 The structure of human Nocturnin reveals a conserved ribonuclease domain that represses target transcript translation and abundance in cells.
ChainA
Resolution2.411 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.108: nocturnin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A N326 H414 N189 H260
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004535 poly(A)-specific ribonuclease activity
Biological Process
GO:0007623 circadian rhythm

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Molecular Function
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Biological Process
External links
PDB RCSB:6bt2, PDBe:6bt2, PDBj:6bt2
PDBsum6bt2
PubMed29860338
UniProtQ9UK39|NOCT_HUMAN Nocturnin (Gene Name=NOCT)

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