Structure of PDB 6bsz Chain A

Receptor sequence
>6bszA (length=445) Species: 9606 (Homo sapiens) [Search protein sequence]
AHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQI
NKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQAKISGVIGAAASSVS
IMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDI
VTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVSIAQSQKIPREPRP
GEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLQQSGHFLWIGSD
SWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWF
AEFWEENFGCKLKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMH
KDLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGR
YDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAHREHTHPASE
3D structure
PDB6bsz Determination of L-AP4-bound human mGlu8 receptor amino terminal domain structure and the molecular basis for L-AP4's group III mGlu receptor functional potency and selectivity.
ChainA
Resolution2.65 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLU A R75 A154 A155 S156 A177 S178 T179 Y227 D309 K401 R39 A95 A96 S97 A118 S119 T120 Y168 D250 K331
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6bsz, PDBe:6bsz, PDBj:6bsz
PDBsum6bsz
PubMed29402739
UniProtO00222|GRM8_HUMAN Metabotropic glutamate receptor 8 (Gene Name=GRM8)

[Back to BioLiP]