Structure of PDB 6bsm Chain A

Receptor sequence
>6bsmA (length=200) Species: 9606 (Homo sapiens) [Search protein sequence]
AATSRPERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERT
DEDSYIVFTYRPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVG
FWHEHTRPDRDRHVSIVRENIQPGQEYNFLKMEPQEVESLGETYDFDSIM
HYARNTFSRGIFLDTIVPKYEVNGVKPPIGQRTRLSKGDIAQARKLYKCP
3D structure
PDB6bsm Reverse Hydroxamate Inhibitors of Bone Morphogenetic Protein 1.
ChainA
Resolution2.33 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.19: procollagen C-endopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H93 H97 H103 H93 H97 H103
BS02 ZN A A1 E104 Q192 A1 E104 Q192
BS03 E7D A C66 S67 Y68 V69 H93 E94 H97 W102 H103 C66 S67 Y68 V69 H93 E94 H97 W102 H103 MOAD: ic50=160nM
PDBbind-CN: -logKd/Ki=6.80,IC50=160nM
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6bsm, PDBe:6bsm, PDBj:6bsm
PDBsum6bsm
PubMed30034610
UniProtP13497|BMP1_HUMAN Bone morphogenetic protein 1 (Gene Name=BMP1)

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