Structure of PDB 6bsd Chain A

Receptor sequence
>6bsdA (length=278) Species: 9606 (Homo sapiens) [Search protein sequence]
DFPRSRLRFKEKLGEGQFGEVHLCEVDSPLLVAVKILRPDATKNARNDFL
KEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLED
KAGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKI
ADFGRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLW
EVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELM
LRCWSRESEQRPPFSQLHRFLAEDALNT
3D structure
PDB6bsd What Makes a Kinase Promiscuous for Inhibitors?
ChainA
Resolution2.606 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D729 R733 N734 D747
Catalytic site (residue number reindexed from 1) D134 R138 N139 D152
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1N1 A L579 V587 A616 K618 M639 T664 Y666 M667 E668 G670 L736 L13 V21 A33 K35 M56 T81 Y83 M84 E85 G87 L141 BindingDB: Kd=0.69nM,IC50=4.8nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6bsd, PDBe:6bsd, PDBj:6bsd
PDBsum6bsd
PubMed30612951
UniProtQ08345|DDR1_HUMAN Epithelial discoidin domain-containing receptor 1 (Gene Name=DDR1)

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