Structure of PDB 6br6 Chain A

Receptor sequence
>6br6A (length=387) Species: 654811 (Influenza A virus (A/Perth/16/2009(H3N2))) [Search protein sequence]
EYRNWSKPQCDITGFAPFSKDNSIRLSAGGDIWVTREPYVSCDPDKCYQF
ALGQGTTLNNVHSNNTVRDRTPYRTLLMNELGVPFHLGTKQVCIAWSSSS
CHDGKAWLHVCITGDDKNATASFIYNGRLVDSVVSWSKEILRTQESECVC
INGTCTVVMTDGSASGKADTKILFIEEGKIVHTSTLSGSAQHVEECSCYP
RYPGVRCVCRDNWKGSNRPIVDINIKDHSIVSSYVCSGLVGDTPRKNDSS
SSSHCLDPNNEEGGHGVKGWAFDDGNDVWMGRTISEKSRLGYETFKVIEG
WSNPKSKLQINRQVIVDRGNRSGYSGIFSVEGKSCINRCFYVELIRGRKE
ETEVLWTSNSIVVFCGTSGTYGTGSWPDGADINLMPI
3D structure
PDB6br6 A Sulfonozanamivir Analogue Has Potent Anti-influenza Virus Activity.
ChainA
Resolution2.03984 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.18: exo-alpha-sialidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D293 G297 D324 G345 H347 D211 G215 D242 G263 H265
BS02 E3M A R118 E119 D151 R152 R224 A246 E276 R292 R371 Y406 R36 E37 D69 R70 R142 A164 E194 R210 R289 Y324 MOAD: Kd=3245nM
Gene Ontology
Molecular Function
GO:0004308 exo-alpha-sialidase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0046761 viral budding from plasma membrane
Cellular Component
GO:0016020 membrane
GO:0033644 host cell membrane
GO:0055036 virion membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6br6, PDBe:6br6, PDBj:6br6
PDBsum6br6
PubMed29453852
UniProtE0UY46

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