Structure of PDB 6bqq Chain A

Receptor sequence
>6bqqA (length=271) Species: 9606 (Homo sapiens) [Search protein sequence]
SMQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRGCIQP
RGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVM
EVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHI
KIADFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAM
GVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQDIAEDLKDLITRML
DKNPESRIVVPEIKLHPWVTR
3D structure
PDB6bqq Crystal Structure of the Human CAMKK2B in complex with BI2526
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D312 K314 N317 D330 T350
Catalytic site (residue number reindexed from 1) D136 K138 N141 D154 T174
Enzyme Commision number 2.7.11.17: calcium/calmodulin-dependent protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 R78 A I171 A192 V249 F267 E268 L269 V270 L319 I13 A34 V73 F91 E92 L93 V94 L143 BindingDB: Kd=23nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6bqq, PDBe:6bqq, PDBj:6bqq
PDBsum6bqq
PubMed
UniProtQ96RR4|KKCC2_HUMAN Calcium/calmodulin-dependent protein kinase kinase 2 (Gene Name=CAMKK2)

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