Structure of PDB 6bqh Chain A

Receptor sequence
>6bqhA (length=351) Species: 562,9606 [Search protein sequence]
FKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSL
AIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHL
CAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLR
DEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQA
ADLEDNWETLNDNLKVIEKAVKDALTKMRAAALDAQKATMKDFRHGFDIL
QLKTTRNAYIQKYLQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVL
CEKSCNQKLMEKLLNVFVWIGYVNSGINPLVYTLFNKIYRRAFSNYLRCN
Y
3D structure
PDB6bqh 5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology.
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 E2J A W130 D134 V135 S138 T139 I142 G218 S219 F223 W324 F327 F328 N351 V354 W85 D89 V90 S93 T94 I97 G173 S174 F178 W288 F291 F292 N315 V318 PDBbind-CN: -logKd/Ki=9.80,Ki=0.16nM
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004993 G protein-coupled serotonin receptor activity
GO:0005506 iron ion binding
GO:0009055 electron transfer activity
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0022900 electron transport chain
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0042597 periplasmic space

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Cellular Component
External links
PDB RCSB:6bqh, PDBe:6bqh, PDBj:6bqh
PDBsum6bqh
PubMed29398112
UniProtP0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC);
P28335|5HT2C_HUMAN 5-hydroxytryptamine receptor 2C (Gene Name=HTR2C)

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