Structure of PDB 6boz Chain A

Receptor sequence
>6bozA (length=139) Species: 9606 (Homo sapiens) [Search protein sequence]
RIDELIESGKEEGMKIDLIDGKGRGVIATKQFSRGDFVVEYHGDLIEITD
AKKREALYAQDPSTGCYMYYFQYLSKTYCVDATRETNRLGRLINHSKSGN
CQTKLHDIDGVPHLILIASRDIAAGEELLYDYGDRSKAS
3D structure
PDB6boz The dynamic conformational landscape of the protein methyltransferase SETD8.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.361: [histone H4]-lysine(20) N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 E1J A Y286 C311 Y312 M313 R336 N339 T348 Y375 Y41 C66 Y67 M68 R91 N94 T103 Y130
BS02 E1J A E300 Q305 P307 C311 E55 Q60 P62 C66
Gene Ontology
Molecular Function
GO:0042799 histone H4K20 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:6boz, PDBe:6boz, PDBj:6boz
PDBsum6boz
PubMed31081496
UniProtQ9NQR1|KMT5A_HUMAN N-lysine methyltransferase KMT5A (Gene Name=KMT5A)

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