Structure of PDB 6box Chain A

Receptor sequence
>6boxA (length=270) Species: 284812 (Schizosaccharomyces pombe 972h-) [Search protein sequence]
DSYTHLSFYEKRELFRKKLREIEGPEVTLVNEVDDEPCPSLDFQFISQYR
LTQGVIPPDPNFQSGCNCSSLGGCDLNNPSRCECLDDLDEPTHFAYDAQG
RVRADTGAVIYECNSFCSCSMECPNRVVQRGRTLPLEIFKTKEKGWGVRS
LRFAPAGTFITCYLGEVITSAEAAKRTYLFDLDMFDEYTVDAQNYGDVSR
FFNHSCSPNIAIYSAVRNHGFRTIYDLAFFAIKDIQPLEELTFDYAGAKD
FSPLRRQCKCGSANCRGWLF
3D structure
PDB6box Automethylation-induced conformational switch in Clr4 (Suv39h) maintains epigenetic stability.
ChainA
Resolution2.412 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.1.1.355: [histone H3]-lysine(9) N-trimethyltransferase.
2.1.1.366: [histone H3]-N(6),N(6)-dimethyl-lysine(9) N-methyltransferase.
2.1.1.367: [histone H3]-lysine(9) N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C477 C484 C258 C265
BS02 ZN A C260 C307 C311 C66 C113 C117
BS03 ZN A C307 C313 C317 C113 C119 C123
BS04 ZN A C260 C268 C276 C66 C74 C82
BS05 SAH A K338 W340 Y381 F407 N409 H410 Y451 C477 K478 F489 K144 W146 Y178 F201 N203 H204 Y245 C258 K259 F270
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0042054 histone methyltransferase activity
GO:0046974 histone H3K9 methyltransferase activity
Cellular Component
GO:0005634 nucleus

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:6box, PDBe:6box, PDBj:6box
PDBsum6box
PubMed30051891
UniProtO60016|CLR4_SCHPO Histone-lysine N-methyltransferase, H3 lysine-9 specific (Gene Name=clr4)

[Back to BioLiP]