Structure of PDB 6bol Chain A

Receptor sequence
>6bolA (length=433) Species: 451804 (Aspergillus fumigatus A1163) [Search protein sequence]
EPDLKTALKAVIPAKRELFKQVKERSDEVIGEVKVANVIGGMRGLKSMLW
EGSVLDPEEGIRFHGKTIKDCQKELPKGTSGTEMLPEAMFWLLLTGQVPS
TNQVRAFSRELAEQSHLPQHILDLIKSFPRSMHPMTQLSIAVAALNTESK
FAKAYEKGLSKADYWEPTFDDSISLLAKIPRVAALVFRPDEVDQVGTQAL
DASQDWSYNFAELLGKGGKENQDFHDLLRLYLALHGDHEGGNVSAHATHL
VGSALSDPFLSYSAGLLGLAGPLHGLAAQEVLRWILAMQDKIGTKFTDDD
VRNYLWDTLKSGRVVPGYGHGVLRKPDPRFQALMDFAATRPDVLANPVFQ
LVKKNSEIAPAVLTEHGKTKNPHPNVDAASGVLFYHYAFQQPLYYTVTFG
VSRALGPLVQLIWDRALGLPIERPKSINLLGLK
3D structure
PDB6bol Comparative studies of Aspergillus fumigatus 2-methylcitrate synthase and human citrate synthase.
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S275 H305 H351 R360 D408
Catalytic site (residue number reindexed from 1) S244 H274 H320 R329 D377
Enzyme Commision number 2.3.3.16: citrate synthase (unknown stereospecificity).
2.3.3.5: 2-methylcitrate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OAA A K46 H95 K15 H64
BS02 OAA A R47 A193 R16 A162
Gene Ontology
Molecular Function
GO:0004108 citrate (Si)-synthase activity
GO:0016740 transferase activity
GO:0036440 citrate synthase activity
GO:0042802 identical protein binding
GO:0046912 acyltransferase activity, acyl groups converted into alkyl on transfer
GO:0050440 2-methylcitrate synthase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006099 tricarboxylic acid cycle
GO:0019629 propionate catabolic process, 2-methylcitrate cycle
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6bol, PDBe:6bol, PDBj:6bol
PDBsum6bol
PubMed31141475
UniProtB0YD89|PRPC_ASPFC 2-methylcitrate synthase, mitochondrial (Gene Name=mcsA)

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