Structure of PDB 6bo7 Chain A

Receptor sequence
>6bo7A (length=220) Species: 5855 (Plasmodium vivax) [Search protein sequence]
HHHKIPNNPGAGENALEPIYIKDDDGYDIDTFLIPDHYKNYITKVLIPNG
VLKNRIEKLAFDIKQVYRNEEFHVICLLKGSRGFFSALLKYLNRIHNYSS
TESPKHLYVEHYVRVKIEIVSEDLSCLKDKHVLIVEDIIDTGKTLLKFCE
YLKKFEVKTIAITCLFIKRTPLWNGFKADFVGFSIPDAFVVGYSLDYNEK
FRDLDHLCLVNDEGIKKFRT
3D structure
PDB6bo7 Design of Plasmodium vivax Hypoxanthine-Guanine Phosphoribosyltransferase Inhibitors as Potential Antimalarial Therapeutics.
ChainA
Resolution2.856 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E144 D145 D148 F197 R210
Catalytic site (residue number reindexed from 1) E136 D137 D140 F189 R202
Enzyme Commision number 2.4.2.8: hypoxanthine phosphoribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A E144 D145 E136 D137
BS02 YPG A K77 D148 T149 G150 T152 K176 F197 V198 L203 D204 R210 K79 D140 T141 G142 T144 K168 F189 V190 L195 D196 R202
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004422 hypoxanthine phosphoribosyltransferase activity
GO:0016757 glycosyltransferase activity
GO:0046872 metal ion binding
GO:0052657 guanine phosphoribosyltransferase activity
Biological Process
GO:0006166 purine ribonucleoside salvage
GO:0006178 guanine salvage
GO:0032263 GMP salvage
GO:0032264 IMP salvage
GO:0046100 hypoxanthine metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6bo7, PDBe:6bo7, PDBj:6bo7
PDBsum6bo7
PubMed29161011
UniProtA5K7E9

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