Structure of PDB 6bni Chain A

Receptor sequence
>6bniA (length=502) Species: 353152 (Cryptosporidium parvum Iowa II) [Search protein sequence]
GSHYTDNRYKMMECIKDAGRPFYPHKFKISMSLPAYALKYGNVENGYIDK
DTTLSLSGRVTSIRSSSSKLIFYDIFCEEQKVQIIANIMEHDISTGEFSV
SHSEIRRGDVVGFTGFPGKSKRGELSLFSKSVVLLSPCYHMLPTAISGLK
DQEVRYRQRYLDLMLNEESRKVFKLRSRAIKYIRNYFDRLGFLEVETPML
NMIYGGAAARPFITYHNELETQLYMRIAPELYLKQLIVGGLDKVYEIGKN
FRNEGIDLTHNPEFTAMEFYMAYADYYDLMDLTEELISGLVLEIHGSLKI
PYHPDGPEGKCIEIDFTTPWKRFSFVEEIESGLGEKLKRPLDSQENIDFM
VEMCEKHEIELPHPRTAAKLLDKLAGHFVETKCTNPSFIIDHPQTMSPLA
KWHREKPEMTERFELFVLGKELCNAYTELNEPLQQRKFFEQQADAKASGD
VEACPIDETFCLALEHGLPPTGGWGLGIDRLIMFLADKNNIKEVILFPAM
RN
3D structure
PDB6bni Crystal Structure of Lysyl-tRNA Synthetase from Cryptosporidium parvum complexed with L-lysine and Adenosine
ChainA
Resolution1.85 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R295 E297 T302 H303 E464 N467 R523
Catalytic site (residue number reindexed from 1) R252 E254 T259 H260 E421 N424 R480
Enzyme Commision number 6.1.1.6: lysine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LYS A G249 E273 E311 Y313 N467 Y469 E471 G516 W517 G206 E230 E268 Y270 N424 Y426 E428 G473 W474
BS02 ADN A H303 N304 F307 E464 L465 G520 R523 H260 N261 F264 E421 L422 G477 R480
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004824 lysine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006430 lysyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:6bni, PDBe:6bni, PDBj:6bni
PDBsum6bni
PubMed
UniProtQ5CR27

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