Structure of PDB 6bn5 Chain A

Receptor sequence
>6bn5A (length=448) Species: 9606 (Homo sapiens) [Search protein sequence]
WFHPNITGVEAENLLLTRGVDGSFLARPSDFTLSVRAVTHIKIQNTGDYY
DLYGGEKFATLAELVQYYMEHIELKYPLNCADPTSERWFHGHLSGKEAEK
LLTHGSFLVREPGDFVLSVRTGDSKVTHVMIRCQELKYDVGGGERFDSLT
DLVEHYKKNPMVETLGTVLQLKQPNTTRINAAIESRVRELSQGFWEEFET
LQQQECKLLYSRKEGQRQENKNKNRYKNILPSDHTRVVLHSDYINANIIM
PKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPD
EYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTW
PDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVID
ILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHY
3D structure
PDB6bn5 Identification of an allosteric benzothiazolopyrimidone inhibitor of the oncogenic protein tyrosine phosphatase SHP2.
ChainA
Resolution2.22 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DZJ A R111 T253 Q257 P491 K492 M496 R87 T200 Q204 P418 K419 M423
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6bn5, PDBe:6bn5, PDBj:6bn5
PDBsum6bn5
PubMed29089257
UniProtQ06124|PTN11_HUMAN Tyrosine-protein phosphatase non-receptor type 11 (Gene Name=PTPN11)

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