Structure of PDB 6bm5 Chain A

Receptor sequence
>6bm5A (length=325) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
TPPVTLEAARDNDFAFDWQAYTPPVAHRLGVQEVEASIETLRNYIDWTPF
FMTWSLAGKYPRILEDEVVGVEAQRLFKDANDMLDKLSAEKTLNPRGVVG
LFPANRVGDDIEIYRDETRTHVINVSHHLRQQTEKTGFANYCLADFVAPK
LSGKADYIGAFAVTGGLEEDALADAFEAQHDDYNKIMVKALADRLAEAFA
EYLHERVRKVYWGYAPNENLSNEELIRENYQGIRPAPGYPACPEHTEKAT
IWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYAVAQIQRDQV
EDYARRKGMSVTEVERWLAPNLGYD
3D structure
PDB6bm5 Water-Mediated Carbon-Oxygen Hydrogen Bonding Facilitates S-Adenosylmethionine Recognition in the Reactivation Domain of Cobalamin-Dependent Methionine Synthase.
ChainA
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.13: methionine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAM A D946 R1134 P1135 A1136 Y1139 P1140 A1141 Y1189 D46 R234 P235 A236 Y239 P240 A241 Y289 MOAD: Kd=1.43uM
PDBbind-CN: -logKd/Ki=5.84,Kd=1.43uM
Gene Ontology
Molecular Function
GO:0008705 methionine synthase activity
Biological Process
GO:0009086 methionine biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6bm5, PDBe:6bm5, PDBj:6bm5
PDBsum6bm5
PubMed29733595
UniProtP13009|METH_ECOLI Methionine synthase (Gene Name=metH)

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