Structure of PDB 6blf Chain A

Receptor sequence
>6blfA (length=348) Species: 9606 (Homo sapiens) [Search protein sequence]
STSLYKKAGFDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMA
ILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFC
YLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAAL
YSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILAT
DLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKT
TRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAM
PIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFL
3D structure
PDB6blf Hydrolase complex
ChainA
Resolution2.11 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.17: 3',5'-cyclic-nucleotide phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DY1 A H656 T768 L770 T805 L809 I826 F830 F862 H88 T200 L202 T237 L241 I258 F262 F294 BindingDB: IC50=7.0nM
BS02 ZN A H660 H696 D697 D808 H92 H128 D129 D240
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:6blf, PDBe:6blf, PDBj:6blf
PDBsum6blf
PubMed
UniProtO00408|PDE2A_HUMAN cGMP-dependent 3',5'-cyclic phosphodiesterase (Gene Name=PDE2A)

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