Structure of PDB 6ble Chain A

Receptor sequence
>6bleA (length=265) Species: 9606 (Homo sapiens) [Search protein sequence]
SMQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQIEQV
YQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKP
LSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGV
SNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCF
VFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPES
RIVVPEIKLHPWVTR
3D structure
PDB6ble Crystal Structure of the Human CAMKK2B in complex with CP673451
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D312 K314 N317 D330 T350
Catalytic site (residue number reindexed from 1) D129 K131 N134 D147 T167
Enzyme Commision number 2.7.11.17: calcium/calmodulin-dependent protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 34U A I171 V179 A192 F267 L269 V270 N271 G273 S316 L319 D330 I13 V21 A34 F84 L86 V87 N88 G90 S133 L136 D147
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6ble, PDBe:6ble, PDBj:6ble
PDBsum6ble
PubMed
UniProtQ96RR4|KKCC2_HUMAN Calcium/calmodulin-dependent protein kinase kinase 2 (Gene Name=CAMKK2)

[Back to BioLiP]