Structure of PDB 6bkw Chain A

Receptor sequence
>6bkwA (length=266) Species: 9606 (Homo sapiens) [Search protein sequence]
GSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEF
IEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHR
FQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGL
SRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYS
LGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERP
TFKILLSNILDVMDEN
3D structure
PDB6bkw Water molecules in protein-ligand interfaces. Evaluation of software tools and SAR comparison.
ChainA
Resolution1.499 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D521 R525 N526 D539
Catalytic site (residue number reindexed from 1) D129 R133 N134 D147
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DXM A L408 T410 G411 F413 V416 K430 Y476 M477 G480 N526 L528 D539 Y551 L16 T18 G19 F21 V24 K38 Y84 M85 G88 N134 L136 D147 Y159 PDBbind-CN: -logKd/Ki=8.30,IC50=5nM
BS02 FPZ A W395 W421 Y425 Y461 W3 W29 Y33 Y69
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6bkw, PDBe:6bkw, PDBj:6bkw
PDBsum6bkw
PubMed30756207
UniProtQ06187|BTK_HUMAN Tyrosine-protein kinase BTK (Gene Name=BTK)

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