Structure of PDB 6bkg Chain A

Receptor sequence

>6bkgA (length=600) Species: 9606 (Homo sapiens) [Search protein sequence]

SQTVASHVPFADLCSTLERIQKSKGRAEKIRHFREFLDSWRKFHDALHKN
DVTDSFYPAMRLILPQLERERMAYGIKETMLAKLYIELLNLPRDGKDALK
LLNYRTPTGDAGDFAMIAYFVLKPRCQKGSLTIQQVNDLLDSIASNNSAK
RKDLIKKSLLQLITQSSALEQKWLIRMIIKDLKLGVSQQTIFSVFHNDAA
ELHNVTTDLEKVCRQLHDPSVGLSDISITLFSAFKPMLAAIADIEHIEKD
MKHQSFYIETKLDGERMQMHKDGDVYKYFSRNGYNYTDQFGASPTEGSLT
PFIHNAFKADIQICILDGEMMAYNPNTQTFMQKGTKFDIKRMDLQTCYCV
FDVLMVNNKKLGHETLRKRYEILSSIFTPIPGRIEIVQKTQAHTKNEVID
ALNEAIDKREEGIMVKQPLSIYKPDKRGEGWLKIKPEYVSGLMDELDILI
VGGYWGKGSRGGMMSHFLCAVAEKPPPGEKPSVFHTLSRVGSGCTMKELY
DLGLKLAKYWKPFHRKAPPSSILCGTEKPEVYIEPCNSVIVQIKAAEIVP
SDMYKTGCTLRFPRIEKIRDDKEWHECMTLDDLEQLRGKASGKLASKHLY

3D structure

PDB

6bkg Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis.

Chain

Resolution

2.402 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

6.5.1.1: DNA ligase (ATP).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	A81 G83 K85 T87 M88 K91 G276 E277 R278 S292 R293 N294 Y296 Y298 K345	A73 G75 K77 T79 M80 K83 G264 E265 R266 S280 R281 N282 Y284 Y286 K333
BS02	dna	A	Q74 K162 Q200 Q201 F349 K473 R476 S481 H482 R505 V506 S567 Y570 L576 F578 P579	Q66 K150 Q188 Q189 F337 K457 R460 S465 H466 R489 V490 S551 Y554 L560 F562 P563
BS03	dna	A	K451 Y454 G509 C510 T511 F578 R580	K435 Y438 G493 C494 T495 F562 R564
BS04	AMP	A	E271 K273 L274 R278 E331 F367 M430 K432 K449	E259 K261 L262 R266 E319 F351 M414 K416 K433

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003909	DNA ligase activity
GO:0003910	DNA ligase (ATP) activity
GO:0005524	ATP binding

	Biological Process
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0051103	DNA ligation involved in DNA repair
GO:0071897	DNA biosynthetic process

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:6bkg, PDBe:6bkg, PDBj:6bkg
PDBsum	6bkg
PubMed	29980672
UniProt	P49917\|DNLI4_HUMAN DNA ligase 4 (Gene Name=LIG4)

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