Structure of PDB 6bid Chain A

Receptor sequence
>6bidA (length=173) Species: 524364 (Norovirus Hu/1968/US) [Search protein sequence]
HAPPTLWSRVTKFGSGWGFWVSPTVFITTTHVVPTGVKEFFGEPLSSIAI
HQAGEFTQFRFSKKMRPDLTGMVLEEGCPEGTVCSVLIKRDSGELLPLAV
RMGAIASMRIQGRLVHGQSGMLLTGANAKGDLGTIPGDCGAPYVHKRGND
WVVCGVHAAATKSGNTVVCAVQA
3D structure
PDB6bid Putative structural rearrangements associated with the interaction of macrocyclic inhibitors with norovirus 3CL protease.
ChainA
Resolution1.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.66: calicivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DW4 A H30 E54 Q110 G133 T134 I135 P136 C139 A158 A159 A160 T161 H31 E55 Q111 G133 T134 I135 P136 C139 A158 A159 A160 T161 PDBbind-CN: -logKd/Ki=5.54,IC50=2.9uM
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6bid, PDBe:6bid, PDBj:6bid
PDBsum6bid
PubMed30883881
UniProtQ83883|POLG_NVN68 Genome polyprotein (Gene Name=ORF1)

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