Structure of PDB 6bic Chain A

Receptor sequence
>6bicA (length=162) Species: 524364 (Norovirus Hu/1968/US) [Search protein sequence]
HAPPTLWSRVTKFGSGWGFWVSPTVFITTTHVVPTEFFGEPLSSIAIHQA
GEFTQFRFSKKMRPDLTGMVLEEGCPEGTVCSVLIKRDSGELLPLAVRMG
AIASMRIQGRLVHGQSGMLLDLGTIPGDCGAPYVHKRNDWVVCGVHAAAT
KSGNTVVCAVQA
3D structure
PDB6bic Putative structural rearrangements associated with the interaction of macrocyclic inhibitors with norovirus 3CL protease.
ChainA
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.66: calicivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5LH A H30 I109 Q110 T134 I135 P136 C139 H157 A158 A159 A160 T161 K162 H31 I107 Q108 T124 I125 P126 C129 H146 A147 A148 A149 T150 K151
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6bic, PDBe:6bic, PDBj:6bic
PDBsum6bic
PubMed30883881
UniProtQ83883|POLG_NVN68 Genome polyprotein (Gene Name=ORF1)

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