Structure of PDB 6bhi Chain A

Receptor sequence
>6bhiA (length=215) Species: 9606 (Homo sapiens) [Search protein sequence]
GELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQTVGPGKKYKVKFDNKGK
SLLSGNHIAYDYHPPDKLYVGSRVVAKYKDGNQVWLYAGIVAETPNVKNK
LRFLIFFDDGYASYVTQSELYPICRPLKKTWEDIEDISCRDFIEEYVTAY
PNRPMVLLKSGQLIKTEAEGTWWKSRVEEVDGSLVRILFLDDKRCEWIYR
GSTRLEPMFSMKTSS
3D structure
PDB6bhi H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1.
ChainA
Resolution1.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.366: [histone H3]-N(6),N(6)-dimethyl-lysine(9) N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A Y268 Y277 F296 G300 Y301 A302 F332 E357 E359 E386 I388 Y389 S392 R394 S404 S405 Y78 Y87 F106 G110 Y111 A112 F142 E167 E169 E196 I198 Y199 S202 R204 S214 S215
External links
PDB RCSB:6bhi, PDBe:6bhi, PDBj:6bhi
PDBsum6bhi
PubMed29234025
UniProtQ15047|SETB1_HUMAN Histone-lysine N-methyltransferase SETDB1 (Gene Name=SETDB1)

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