Structure of PDB 6bhh Chain A

Receptor sequence
>6bhhA (length=210) Species: 9606 (Homo sapiens) [Search protein sequence]
GELSKDGDLIVSMRILGKKRTKTWHKGTLIAIQTVGPGKKYKVKFDNKGK
SLLSGNHIAYDYHPPADKLYVGSRVVAKYKQVWLYAGIVAETPNVKNKLR
FLIFFDDGYASYVTQSELYPICRPLKKTWEDIEDISCRDFIEEYVTAYPN
RPMVLLKSGQLIKTEAEGTWWKSRVEEVDGSLVRILFLDDKRCEWIYRGS
TRLEPMFSMK
3D structure
PDB6bhh H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1.
ChainA
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.366: [histone H3]-N(6),N(6)-dimethyl-lysine(9) N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A F296 G300 Y301 A302 F332 E357 I388 Y389 S392 R394 F104 G108 Y109 A110 F140 E165 I196 Y197 S200 R202
External links
PDB RCSB:6bhh, PDBe:6bhh, PDBj:6bhh
PDBsum6bhh
PubMed29234025
UniProtQ15047|SETB1_HUMAN Histone-lysine N-methyltransferase SETDB1 (Gene Name=SETDB1)

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