Structure of PDB 6bh3 Chain A

Receptor sequence
>6bh3A (length=302) Species: 9606 (Homo sapiens) [Search protein sequence]
AEFVPPPECPVFEPSWEEFTDPLSFIGRIRPLAEKTGICKIRPPKDWQPP
FACEVKSFRFTPRVQRLNELEAMTFGFEQAVREYTLQSFGEMADNFKSDY
FNMPVHMVPTELVEKEFWRLVSSIEEDVIVEYGADISSKDFGSGFPVKDG
RRKILPEEEEYALSGWNLNNMPVLEQSVLMKVPWLYVGMCFSSFCWHIED
HWSYSINYLHWGEPKTWYGVPSHAAEQLEEVMRELAPELFESQPDLLHQL
VTIMNPNVLMEHGVPVYRTNQCAGEFVVTFPRAYHSGFNQGYNFAEAVNF
CT
3D structure
PDB6bh3 Insights into the Action of Inhibitor Enantiomers against Histone Lysine Demethylase 5A.
ChainA
Resolution1.701 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y472 H483 E485 H571 A583
Catalytic site (residue number reindexed from 1) Y186 H197 E199 H285 A297
Enzyme Commision number 1.14.11.67: [histone H3]-trimethyl-L-lysine(4) demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DQJ A Y472 S479 F480 H483 E485 K501 H571 A583 V584 Y186 S193 F194 H197 E199 K215 H285 A297 V298 PDBbind-CN: -logKd/Ki=4.92,Kd>12uM
BindingDB: EC50=1600nM,IC50=90nM
BS02 MN A H483 E485 H571 H197 E199 H285
External links
PDB RCSB:6bh3, PDBe:6bh3, PDBj:6bh3
PDBsum6bh3
PubMed29537847
UniProtP29375|KDM5A_HUMAN Lysine-specific demethylase 5A (Gene Name=KDM5A)

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