Structure of PDB 6bh2 Chain A

Receptor sequence
>6bh2A (length=295) Species: 9606 (Homo sapiens) [Search protein sequence]
AEFVPPPECPVFEPSWEEFTDPLSFIGRIRPLAEKTGICKIRPPKDWQPP
FACEVKSFRFTPRVQRLNELEAMFGFEREYTLQSFGEMADNFKSDYFNMP
VHMVPTELVEKEFWRLVSSIEEDVIVEYGADISSKDFGSGFPVKDGRRKI
LPEEEEYALSGWNLNNMPVLEQMKVPWLYVGMCFSSFCWHIEDHWSYSIN
YLHWGEPKTWYGVPSHAAEQLEEVMRELAPELFESQPDLLHQLVTIMNPN
VLMEHGVPVYRTNQCAGEFVVTFPRAYHSGFNQGYNFAEAVNFCT
3D structure
PDB6bh2 Insights into the Action of Inhibitor Enantiomers against Histone Lysine Demethylase 5A.
ChainA
Resolution1.447 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y472 H483 E485 H571 A583
Catalytic site (residue number reindexed from 1) Y179 H190 E192 H278 A290
Enzyme Commision number 1.14.11.67: [histone H3]-trimethyl-L-lysine(4) demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A H483 E485 H571 H190 E192 H278
BS02 90V A Y472 S479 F480 H483 E485 K501 H571 N575 V584 N585 Y179 S186 F187 H190 E192 K208 H278 N282 V291 N292 MOAD: Kd=2.4uM
PDBbind-CN: -logKd/Ki=5.62,Kd=2.4uM
BindingDB: IC50=570nM,Kd=2400nM,EC50=960nM
External links
PDB RCSB:6bh2, PDBe:6bh2, PDBj:6bh2
PDBsum6bh2
PubMed29537847
UniProtP29375|KDM5A_HUMAN Lysine-specific demethylase 5A (Gene Name=KDM5A)

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