Structure of PDB 6bh1 Chain A

Receptor sequence
>6bh1A (length=297) Species: 9606 (Homo sapiens) [Search protein sequence]
AEFVPPPECPVFEPSWEEFTDPLSFIGRIRPLAEKTGICKIRPPKDWQPP
FACEVKSFRFTPRVQRLNELEAMTQAVREYTLQSFGEMADNFKSDYFNMP
VHMVPTELVEKEFWRLVSSIEEDVIVEYGADISSKDFGSGFPVKDGRRKI
LPEEEEYALSGWNLNNMPVLEQSVLKVPWLYVGMCFSSFCWHIEDHWSYS
INYLHWGEPKTWYGVPSHAAEQLEEVMRELAPELFESQPDLLHQLVTIMN
PNVLMEHGVPVYRTNQCAGEFVVTFPRAYHSGFNQGYNFAEAVNFCT
3D structure
PDB6bh1 Insights into the Action of Inhibitor Enantiomers against Histone Lysine Demethylase 5A.
ChainA
Resolution1.932 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y472 H483 E485 H571 A583
Catalytic site (residue number reindexed from 1) Y181 H192 E194 H280 A292
Enzyme Commision number 1.14.11.67: [histone H3]-trimethyl-L-lysine(4) demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DQG A Y409 D412 W470 Y472 F480 C481 H483 N493 K501 W503 H571 Y128 D131 W179 Y181 F189 C190 H192 N202 K210 W212 H280 MOAD: Kd=0.06uM
PDBbind-CN: -logKd/Ki=7.22,Kd=0.06uM
BindingDB: Kd=60nM,IC50=590nM
BS02 MN A H483 E485 H571 H192 E194 H280
External links
PDB RCSB:6bh1, PDBe:6bh1, PDBj:6bh1
PDBsum6bh1
PubMed29537847
UniProtP29375|KDM5A_HUMAN Lysine-specific demethylase 5A (Gene Name=KDM5A)

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