Structure of PDB 6bgz Chain A

Receptor sequence
>6bgzA (length=293) Species: 9606 (Homo sapiens) [Search protein sequence]
AEFVPPPECPVFEPSWEEFTDPLSFIGRIRPLAEKTGICKIRPPKDWQPP
FACEVKSFRFTPRVQRLNELEAMAVREYTLQSFGEMADNFKSDYFNMPVH
MVPTELVEKEFWRLVSSIEEDVIVEYGADISSKDFGSGFPVKDGRRKILP
EEEEYALSGWNLNNMPVLEQSKVPWLYVGMCFSSFCWHIEDHWSYSINYL
HWGEPKTWYGVPSHAAEQLEEVMRELAPELFESQPDLLHQLVTIMNPNVL
MEHGVPVYRTNQCAGEFVVTFPRAYHSGFNQGYNFAEAVNFCT
3D structure
PDB6bgz Insights into the Action of Inhibitor Enantiomers against Histone Lysine Demethylase 5A.
ChainA
Resolution1.688 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) Y472 H483 E485 H571 A583
Catalytic site (residue number reindexed from 1) Y177 H188 E190 H276 A288
Enzyme Commision number 1.14.11.67: [histone H3]-trimethyl-L-lysine(4) demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DNV A Y409 Y472 F480 C481 H483 K501 W503 Q535 L536 H571 Y126 Y177 F185 C186 H188 K206 W208 Q240 L241 H276 MOAD: Kd=0.41uM
PDBbind-CN: -logKd/Ki=6.39,Kd=0.41uM
BindingDB: Kd=410nM,IC50=1400nM
BS02 MN A H483 E485 H571 H188 E190 H276
External links
PDB RCSB:6bgz, PDBe:6bgz, PDBj:6bgz
PDBsum6bgz
PubMed29537847
UniProtP29375|KDM5A_HUMAN Lysine-specific demethylase 5A (Gene Name=KDM5A)

[Back to BioLiP]