Structure of PDB 6bgx Chain A

Receptor sequence
>6bgxA (length=308) Species: 9606 (Homo sapiens) [Search protein sequence]
EFVPPPECPVFEPSWEEFTDPLSFIGRIRPLAEKTGICKIRPPKDWQPPF
ACEVKSFRFTPRVQRLNELEAMRPREAFGFEQAVREYTLQSFGEMADNFK
SDYFNMPVHMVPTELVEKEFWRLVSSIEEDVIVEYGADISSKDFGSGFPV
KDGRRKILPEEEEYALSGWNLNNMPVLEQSVLAHINKVPWLYVGMCFSSF
CWHIEDHWSYSINYLHWGEPKTWYGVPSHAAEQLEEVMRELAPELFESQP
DLLHQLVTIMNPNVLMEHGVPVYRTNQCAGEFVVTFPRAYHSGFNQGYNF
AEAVNFCT
3D structure
PDB6bgx Insights into the Action of Inhibitor Enantiomers against Histone Lysine Demethylase 5A.
ChainA
Resolution1.882 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y472 H483 E485 H571 A583
Catalytic site (residue number reindexed from 1) Y192 H203 E205 H291 A303
Enzyme Commision number 1.14.11.67: [histone H3]-trimethyl-L-lysine(4) demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DKV A Y409 Y472 F480 C481 H483 D486 K501 W503 H571 Y135 Y192 F200 C201 H203 D206 K221 W223 H291 MOAD: Kd=0.47uM
PDBbind-CN: -logKd/Ki=6.33,Kd=0.47uM
BindingDB: Kd=470nM,IC50=22000nM
BS02 MN A H483 E485 H571 H203 E205 H291
External links
PDB RCSB:6bgx, PDBe:6bgx, PDBj:6bgx
PDBsum6bgx
PubMed29537847
UniProtP29375|KDM5A_HUMAN Lysine-specific demethylase 5A (Gene Name=KDM5A)

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