Structure of PDB 6bgp Chain A

Receptor sequence
>6bgpA (length=303) Species: 9606 (Homo sapiens) [Search protein sequence]
EKTFEQLHKKCLEKKVLYVDPEFPPDETSLFYSQFVWKRPPEICENPRFI
IDGANRTDICQGELGDAWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGI
FHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKL
HGSYEALKGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLM
GCSIDDGYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPWGQVE
WNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEIC
NLT
3D structure
PDB6bgp Structures of human calpain-3 protease core with and without bound inhibitor reveal mechanisms of calpain activation.
ChainA
Resolution2.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q123 A129 H334 N358 W360
Catalytic site (residue number reindexed from 1) Q61 A67 H220 N244 W246
Enzyme Commision number 3.4.22.54: calpain-3.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A I113 G115 D120 E199 I51 G53 D58 E137
BS02 CA A E364 D371 T392 D394 E396 E250 D257 T278 D280 E282
Gene Ontology
Molecular Function
GO:0004198 calcium-dependent cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6bgp, PDBe:6bgp, PDBj:6bgp
PDBsum6bgp
PubMed29382717
UniProtP20807|CAN3_HUMAN Calpain-3 (Gene Name=CAPN3)

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