Structure of PDB 6bfn Chain A

Receptor sequence
>6bfnA (length=301) Species: 9606 (Homo sapiens) [Search protein sequence]
SRPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKRLK
EWTAVKQSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLE
DRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVL
LDERLTPKLGDFGLARFSRTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVV
VLETLAGQRAVKTHGARTKYLKDLVEEEAEEAGVAAADAWAAPIAMQIYK
KHLDPRPGPCPPELGLGLGQLACCCLHRRAKRRPPMTQVYERLEKLQAVV
A
3D structure
PDB6bfn Crystal structure of human IRAK1.
ChainA
Resolution2.26 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DL1 A I218 A237 Y288 F290 L291 G294 L347 D358 I26 A45 Y91 F93 L94 G97 L150 D161 MOAD: ic50=9.3nM
PDBbind-CN: -logKd/Ki=8.03,IC50=9.3nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6bfn, PDBe:6bfn, PDBj:6bfn
PDBsum6bfn
PubMed29208712
UniProtP51617|IRAK1_HUMAN Interleukin-1 receptor-associated kinase 1 (Gene Name=IRAK1)

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