Structure of PDB 6bdt Chain A

Receptor sequence
>6bdtA (length=307) Species: 9606 (Homo sapiens) [Search protein sequence]
EKTFEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFQFVWKRPPEICENP
RFIIDGANRTDICQGELGDSWFLAAIACLTLNQHLLFRVIPHDQSFIENY
AGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAY
AKLHGSYEALKGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERG
SLMGCSIDDGTTRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPWGQ
VEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLE
ICNLTAD
3D structure
PDB6bdt Structures of human calpain-3 protease core with and without bound inhibitor reveal mechanisms of calpain activation.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) Q123 S129 H334 N358 W360
Catalytic site (residue number reindexed from 1) Q64 S70 H222 N246 W248
Enzyme Commision number 3.4.22.54: calpain-3.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A I113 G115 D120 E199 I54 G56 D61 E140
BS02 CA A E364 D371 T392 D394 E396 E252 D259 T280 D282 E284
Gene Ontology
Molecular Function
GO:0004198 calcium-dependent cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6bdt, PDBe:6bdt, PDBj:6bdt
PDBsum6bdt
PubMed29382717
UniProtP20807|CAN3_HUMAN Calpain-3 (Gene Name=CAPN3)

[Back to BioLiP]