Structure of PDB 6bd2 Chain A

Receptor sequence
>6bd2A (length=229) Species: 9606 (Homo sapiens) [Search protein sequence]
EKTELIQKAKLAEQAERYDDMATCMKAVTEQGAELSNEERNLLSVAYKNV
VGGRRSAWRVISSIEQKTDTSDKKLQLIKDYREKVESELRSICTTVLELL
DKYLIANATNPESKVFYLKMKGDYFRYLAEVACGDDRKQTIDNSQGAYQE
AFDISKKEMQPTHPIRLGLALNFSVFYYEILNNPELACTLAKTAFDEAIA
ELDTLNEDSYKDSTLIMQLLRDNLTLWTS
3D structure
PDB6bd2 Mechanism of IRSp53 inhibition by 14-3-3.
ChainA
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K49 N50 G53 R56 R60 R127 L172 N173 V176 I217 N224 W228 K48 N49 G52 R55 R59 R126 L171 N172 V175 I216 N223 W227
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0019904 protein domain specific binding
GO:0042802 identical protein binding
GO:0044325 transmembrane transporter binding
GO:0071889 14-3-3 protein binding
Biological Process
GO:0006605 protein targeting
GO:0007165 signal transduction
GO:0007264 small GTPase-mediated signal transduction
GO:0008104 protein localization
GO:0021762 substantia nigra development
GO:0034766 negative regulation of monoatomic ion transmembrane transport
GO:0045892 negative regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005925 focal adhesion
GO:0016020 membrane
GO:0032991 protein-containing complex
GO:0045202 synapse
GO:0070062 extracellular exosome

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Cellular Component
External links
PDB RCSB:6bd2, PDBe:6bd2, PDBj:6bd2
PDBsum6bd2
PubMed30696821
UniProtP27348|1433T_HUMAN 14-3-3 protein theta (Gene Name=YWHAQ)

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