Structure of PDB 6bcq Chain A

Receptor sequence
>6bcqA (length=983) Species: 10090 (Mus musculus) [Search protein sequence]
PKIFRKKVCTTFITTEKPTDAYGDLDFTYSGRKHSNFLRLSDRTDPATVY
SLVTRSWGFRAPNLVVSVLGGSGGPVLQTWLQDLLRRGLVRAAQSTGAWI
VTGGLHTGIGRHVGVAVRDHQTASTGSSKVVAMGVAPWGVVRNRDMLINP
KGSFPARYRWRGDPEDGVEFPLDYNYSAFFLVDDGTYGRLGGENRFRLRF
ESYVAQQKTGVGGTGIDIPVLLLLIDGDEKMLKRIEDATQAQLPCLLVAG
SGGAADCLVETLEEARDRIRRYFPKGDPEVLQAQVERIMTRKELLTVYSS
EDGSEEFETIVLRALVKACGSSEASAYLDELRLAVAWNRVDIAQSELFRG
DIQWRSFHLEASLMDALLNDRPEFVRLLISHGLSLGHFLTPVRLAQLYSA
VSPNSLIRNLLDQASHAPNVGQVLRTLLGETCAPRYAPWSDLLIWALLLN
RAQMAIYFWEKGSNSVASALGACLLLRVMARLESEAEEAARRKDLAATFE
SMSVDLFGECYHNSEERAARLLLRRCPLWGEATCLQLAMQADARAFFAQD
GVQSLLTQKWWGEMDSTTPIWALLLAFFCPPLIYTNLIVFRKSKRWSDFW
GAPVTAFLGNVVSYLLFLLLFAHVLLVDFQPTKPSVSELLLYFWAFTLLC
EELRQGLGLRHRLHLYLSDTWNQCDLLALTCFLLGVGCRLTPGLFDLGRT
VLCLDFMIFTLRLLHIFTVNKQLGPKIVIVSKMMKDVFFFLFFLCVWLVA
YGVATEGILRPQDRSLPSILRRVFYRPYLQIFGQIPQEEMDVALMIPGNC
SMERGSWAHPEGPVAGSCVSQYANWLVVLLLIVFLLVANILLLNLLIAMF
SYTFSKVHGNSDLYWKAQRYSLIREFHSRPALAPPLIIISHVRLLIKWLR
RLSKEAERKLLTWESVHKENFLLAQARDKRDSDSERLKRTSQKVDTALKQ
LGQIREYDRRLRGLEREVQHCSRVLTWMAEALS
3D structure
PDB6bcq Structures of the calcium-activated, non-selective cation channel TRPM4.
ChainA
Resolution3.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A H160 R172 W214 R215 L226 D227 Y228 H106 R118 W160 R161 L172 D173 Y174
BS02 ATP A R422 G449 R355 G382
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005227 calcium-activated cation channel activity
GO:0005244 voltage-gated monoatomic ion channel activity
GO:0005261 monoatomic cation channel activity
GO:0005262 calcium channel activity
GO:0005509 calcium ion binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0002250 adaptive immune response
GO:0002407 dendritic cell chemotaxis
GO:0002724 regulation of T cell cytokine production
GO:0006811 monoatomic ion transport
GO:0006816 calcium ion transport
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0008284 positive regulation of cell population proliferation
GO:0010460 positive regulation of heart rate
GO:0016925 protein sumoylation
GO:0019722 calcium-mediated signaling
GO:0030502 negative regulation of bone mineralization
GO:0034220 monoatomic ion transmembrane transport
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0042391 regulation of membrane potential
GO:0045600 positive regulation of fat cell differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0045907 positive regulation of vasoconstriction
GO:0051289 protein homotetramerization
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0071318 cellular response to ATP
GO:0086045 membrane depolarization during AV node cell action potential
GO:0086047 membrane depolarization during Purkinje myocyte cell action potential
GO:0086048 membrane depolarization during bundle of His cell action potential
GO:0086091 regulation of heart rate by cardiac conduction
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0098662 inorganic cation transmembrane transport
GO:0098719 sodium ion import across plasma membrane
GO:0098911 regulation of ventricular cardiac muscle cell action potential
GO:1903949 positive regulation of atrial cardiac muscle cell action potential
GO:1904179 positive regulation of adipose tissue development
GO:1904199 positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization
Cellular Component
GO:0005654 nucleoplasm
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0034706 sodium channel complex
GO:0043025 neuronal cell body

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6bcq, PDBe:6bcq, PDBj:6bcq
PDBsum6bcq
PubMed29211714
UniProtQ7TN37|TRPM4_MOUSE Transient receptor potential cation channel subfamily M member 4 (Gene Name=Trpm4)

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