Structure of PDB 6bc4 Chain A

Receptor sequence
>6bc4A (length=268) Species: 550 (Enterobacter cloacae) [Search protein sequence]
TPWSKSELVRQLRDLGVRSGDMVMPHVSLRAVGPLADGPQTLVDALIEAV
GPTGNILAFVSWRDSPYEQTLGHDAPPAAIAQSWPAFDPDHAPAYPGFGA
INEFIRTYPGCRRTAHPDASMAAIGPDAAWLVAPHEMGAAYGPRSPIARF
LAHAGKILSIGAGPDAVTALHYAEAVARIEGKRRVTYSMPLLREGKRVWV
TTSDWDSNGILDEYAAPDGPDAVERIARDYLARTRVAQGPVGGAQSRLID
AADIVSFGIEWLEARHAA
3D structure
PDB6bc4 A low-barrier hydrogen bond mediates antibiotic resistance in a noncanonical catalytic triad.
ChainA
Resolution2.049 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.81: aminoglycoside N(3)-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACO A H44 V45 S46 L47 R48 P57 F77 F116 G117 A118 F122 A180 D183 A184 V185 T186 H189 H26 V27 S28 L29 R30 P39 F59 F98 G99 A100 F104 A162 D165 A166 V167 T168 H171
Gene Ontology
Molecular Function
GO:0008080 N-acetyltransferase activity
GO:0016746 acyltransferase activity
GO:0046353 aminoglycoside 3-N-acetyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0046677 response to antibiotic

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Molecular Function
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Biological Process
External links
PDB RCSB:6bc4, PDBe:6bc4, PDBj:6bc4
PDBsum6bc4
PubMed29632894
UniProtQ47030

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