Structure of PDB 6bc3 Chain A

Receptor sequence
>6bc3A (length=268) Species: 550 (Enterobacter cloacae) [Search protein sequence]
TPWSKSELVRQLRDLGVRSGDMVMPHVSLRAVGPLADGPQTLVDALIEAV
GPTGNILAFVSWRDSPYEQTLGHDAPPAAIAQSWPAFDPDHAPAYPGFGA
INEFIRTYPGCRRTAHPDASMAAIGPDAAWLVAPHEMGAAYGPRSPIARF
LAHAGKILSIGAGPDAVTALHYAEAVARIEGKRRVTYSMPLLREGKRVWV
TTSDWDSNGILDEYAAPDGPDAVERIARDYLARTRVAQGPVGGAQSRLID
AADIVSFGIEWLEARHAA
3D structure
PDB6bc3 A low-barrier hydrogen bond mediates antibiotic resistance in a noncanonical catalytic triad.
ChainA
Resolution2.047 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.81: aminoglycoside N(3)-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 COA A H44 V45 S46 L47 R48 F77 F116 G117 A118 F122 A180 A184 T186 H26 V27 S28 L29 R30 F59 F98 G99 A100 F104 A162 A166 T168
BS02 SIS A Y85 E86 Y113 D136 D183 H189 S225 N226 Y67 E68 Y95 D118 D165 H171 S207 N208
Gene Ontology
Molecular Function
GO:0008080 N-acetyltransferase activity
GO:0016746 acyltransferase activity
GO:0046353 aminoglycoside 3-N-acetyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0046677 response to antibiotic

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Molecular Function
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Biological Process
External links
PDB RCSB:6bc3, PDBe:6bc3, PDBj:6bc3
PDBsum6bc3
PubMed29632894
UniProtQ47030

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