Structure of PDB 6bba Chain A

Receptor sequence
>6bbaA (length=189) Species: 9606 (Homo sapiens) [Search protein sequence]
SLIPIVVEQTGRGERAYDIYSRLLRERIVCVMGPIDDSVASLVIAQLLFL
QSESNKKPIHMYINSPGGVVTAGLAIYDTMQYILNPICTWCVGQAASMGS
LLLAAGTPGMRHSLPNSRIMIHQPSATDIAIQAEEIMKLKKQLYNIYAKH
TKQSLQVIESAMERDRYMSPMEAQEFGILDKVLVHPPQD
3D structure
PDB6bba Acyldepsipeptide Analogs Dysregulate Human Mitochondrial ClpP Protease Activity and Cause Apoptotic Cell Death.
ChainA
Resolution2.796 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.92: endopeptidase Clp.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R121 L122 I127 H159 Y161 W189 R22 L23 I28 H60 Y62 W90
BS02 peptide A L147 F148 S151 T178 Y181 L48 F49 S52 T79 Y82
Gene Ontology
Molecular Function
GO:0004176 ATP-dependent peptidase activity
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6bba, PDBe:6bba, PDBj:6bba
PDBsum6bba
PubMed30126533
UniProtQ16740|CLPP_HUMAN ATP-dependent Clp protease proteolytic subunit, mitochondrial (Gene Name=CLPP)

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