Structure of PDB 6ba2 Chain A

Receptor sequence
>6ba2A (length=264) Species: 9606 (Homo sapiens) [Search protein sequence]
KYVDKIHIGNYEIDAWYFSPFPEDYGKQPKLWLCEYCLKYMKYEKSYRFH
LGQCQWRQPPGKEIYRKSNISVHEVDGKDHKIYCQNLCLLAKLFLDHKTL
YFDVEPFVFYILTEVDRQGAHIVGYFSKEKESPDGNNVSCIMILPPYQRR
GYGRFLIAFSYELSKLESTVGSPEKPLSDLGKLSYRSYWSSVLLENLRDL
SIKDLSQMTSITQNDIISTLQSLNMVKYWKGQHVICVTPKLVEEHLKKKP
PITVDSVCLKWAPP
3D structure
PDB6ba2 Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth.
ChainA
Resolution1.85004 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C540 C543 H556 C560 C34 C37 H50 C54
BS02 7KM A L601 I647 I649 Q654 R655 G657 G659 R660 S684 L686 S690 S693 L95 I141 I143 Q148 R149 G151 G153 R154 S178 L180 S184 S187
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:6ba2, PDBe:6ba2, PDBj:6ba2
PDBsum6ba2
PubMed30069049
UniProtQ9H7Z6|KAT8_HUMAN Histone acetyltransferase KAT8 (Gene Name=KAT8)

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