Structure of PDB 6b9l Chain A

Receptor sequence
>6b9lA (length=174) Species: 9606 (Homo sapiens) [Search protein sequence]
KEVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMNDMPIYMYSVCNVMSGD
QDNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFNLYYAES
DLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTRK
GFYLAFQDIGACVALLSVRVYYKK
3D structure
PDB6b9l Structure-Based Design of Novel EphA2 Agonistic Agents with Nanomolar Affinity in Vitro and in Cell.
ChainA
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A E40 L54 M55 Q56 N57 Y65 M66 R103 F108 F156 R159 V161 C188 V189 E14 L28 M29 Q30 N31 Y39 M40 R77 F82 F130 R133 V135 C162 V163
BS02 peptide A V72 M73 V46 M47
BS03 peptide A Y123 K141 I142 S169 V170 G171 Y97 K115 I116 S143 V144 G145
External links
PDB RCSB:6b9l, PDBe:6b9l, PDBj:6b9l
PDBsum6b9l
PubMed30110533
UniProtP29317|EPHA2_HUMAN Ephrin type-A receptor 2 (Gene Name=EPHA2)

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