Structure of PDB 6b98 Chain A

Receptor sequence
>6b98A (length=344) Species: 9606 (Homo sapiens) [Search protein sequence]
TSLYKKAGFYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSM
LQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLY
KNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSE
GSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAH
HLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKI
AELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYK
LLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFL
3D structure
PDB6b98 The identification of a novel lead class for phosphodiesterase 2 inhibition by fragment-based drug design.
ChainA
Resolution1.97 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.17: 3',5'-cyclic-nucleotide phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H660 H696 D697 D808 H88 H124 D125 D236
BS02 D07 A L809 I826 F862 L237 I254 F290 MOAD: Ki=22.4uM
PDBbind-CN: -logKd/Ki=4.65,Ki=22.4uM
BindingDB: Ki=22400nM
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:6b98, PDBe:6b98, PDBj:6b98
PDBsum6b98
PubMed29113762
UniProtO00408|PDE2A_HUMAN cGMP-dependent 3',5'-cyclic phosphodiesterase (Gene Name=PDE2A)

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