Structure of PDB 6b82 Chain A

Receptor sequence
>6b82A (length=465) Species: 7955 (Danio rerio) [Search protein sequence]
RSPPSLPSLPIIGSLMSLVSDSPPHIFFQDLQKKYGDLYSLMMGSHKLLI
VNNHHHAKEILIKKGKIFAGRPRTVTTDLLTRDGKDIAFADYSSTWKFHR
KMVHGALCMFGEGSVSIEKIICREASSMCEVLTESQNLGPELTRAVTNVV
CALCFNSSYKRGDAEFESMLQYSQGIVDTVAKDSLVDIFPWLQIFPNKDL
RILRQCISIRDKLLQKKYEEHKVTYSDNVQRDLLDALLRAKRSSENNNSS
TRDVGLTEDHVLMTVGEIFGAGVETTTTTLKWSIAYLVHNPQVQRKIQEE
LDSKIGKERHPQLSDRGNLPYLEATICEVMRIRPVSPLLIPHVALQDSSV
GEYTVQKGTRVVINMWSLHHDEKEWKNPELFDPGRFLNEEGDGLCCPSGS
YLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEMPTGQPLPDLQGKFG
VVLQPKKFKVVAKVR
3D structure
PDB6b82 Inherent steroid 17 alpha ,20-lyase activity in defunct cytochrome P450 17A enzymes.
ChainA
Resolution3.03 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.14.19: steroid 17alpha-monooxygenase.
1.14.14.32: 17alpha-hydroxyprogesterone deacetylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM A R109 A126 W134 R138 A313 T317 T321 V377 H384 P445 F446 R451 C453 L454 G455 R71 A88 W96 R100 A271 T275 T279 V335 H342 P403 F404 R409 C411 L412 G413
BS02 AER A S215 V219 E309 G312 T317 V377 S378 S173 V177 E267 G270 T275 V335 S336
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0004508 steroid 17-alpha-monooxygenase activity
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016829 lyase activity
GO:0020037 heme binding
GO:0046872 metal ion binding
GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity
Biological Process
GO:0006694 steroid biosynthetic process
GO:0030237 female sex determination
GO:0030238 male sex determination
GO:0042446 hormone biosynthetic process
GO:0042448 progesterone metabolic process
GO:1903449 androst-4-ene-3,17-dione biosynthetic process
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6b82, PDBe:6b82, PDBj:6b82
PDBsum6b82
PubMed29212707
UniProtA0A8M1PIC7

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