Structure of PDB 6b7h Chain A

Receptor sequence
>6b7hA (length=441) Species: 9606 (Homo sapiens) [Search protein sequence]
RREIKIGDLVLGGLFPINEKEECGRINEDRGIQRLEAMLFAIDEINKDDY
LLPGVKLGVHILDTCSRDTYALEQSLEFVRASLPLLIAGVIGGSYSSVSI
QVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEIL
RFFNWTYVSTVASEGDYGETGIEAFEQEARLRNISIATAEKVGRSNIRKS
YDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRANASFTWVASDGWGA
QESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFW
EQKFQCSLRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLC
PNTTKLCDAMKILDGKKLYKDYLLKINFTAPDADSIVKFDTFGDGMGRYN
VFNFQNVGGKYSYLKVGHWAETLSLDVNSIHWSRNSVPTSE
3D structure
PDB6b7h Synthesis and Pharmacological Characterization of C4beta-Amide-Substituted 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1 S,2 S,4 S,5 R,6 S)-2-Amino-4-[(3-methoxybenzoyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2794193), a Highly Potent and Selective mGlu3Receptor Agonist.
ChainA
Resolution2.82 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CWY A R64 R68 Y150 S151 A172 S173 T174 Y222 R277 S278 D279 D301 K389 R30 R34 Y95 S96 A117 S118 T119 Y167 R222 S223 D224 D246 K327 PDBbind-CN: -logKd/Ki=9.03,Ki=0.927nM
BindingDB: EC50=12nM,Ki=0.927000nM
BS02 CA A I79 N80 L86 P87 I45 N46 L52 P53
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:6b7h, PDBe:6b7h, PDBj:6b7h
PDBsum6b7h
PubMed29350927
UniProtQ14832|GRM3_HUMAN Metabotropic glutamate receptor 3 (Gene Name=GRM3)

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