Structure of PDB 6b6k Chain A

Receptor sequence
>6b6kA (length=283) Species: 6183 (Schistosoma mansoni) [Search protein sequence]
PVVANYENASMAADYIKRVSNVLPDIGIICGSGLGKLIEEIEERKVIPYI
NIPNFPKTTVAGHVGNLVLGSVGGRKIVAMQGRLHMYEGYSNQEIALPIR
VMKLLGVRVLLITNLAGGINRKLKSGDFVLIKGHINFPGLGLNNVLVGPN
QDEFGPRFPDLSNAYDRLLQQLALKIAQENDFQDLVHEGVYAFNGGPTYE
SPDESNMLLKLGCDVVGMSTVPEVIIACHCGIKVLAVSLIANNSILDAEN
DVSINHEKVLAVAEKRADLLQMWFKEIITRLPL
3D structure
PDB6b6k Crystal Structure of Purine Nucleoside Phosphorylase Isoform 2 from Schistosoma mansoni in complex with 3-methylpyridazin-1-ium-6-olate
ChainA
Resolution1.46 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S35 H66 H88 Y90 E91 L118 M221 S222 N245 H259
Catalytic site (residue number reindexed from 1) S32 H63 H85 Y87 E88 L115 M218 S219 N242 H256
Enzyme Commision number 2.4.2.1: purine-nucleoside phosphorylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CVG A A119 G120 Y202 E203 M221 A116 G117 Y199 E200 M218
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004731 purine-nucleoside phosphorylase activity
GO:0016757 glycosyltransferase activity
GO:0047975 guanosine phosphorylase activity
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0009116 nucleoside metabolic process
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:6b6k, PDBe:6b6k, PDBj:6b6k
PDBsum6b6k
PubMed
UniProtA0A0U3AGT1

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