Structure of PDB 6b6d Chain A

Receptor sequence
>6b6dA (length=265) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
DLADRFAELERRYDARLGVYVPATGTTAAIEYRADERFAFCSTFKAPLVA
AVLHQNPLTHLDKLITYTSDDIRSISPVAQQHVQTGMTIGQLCDAAIRYS
DGTAANLLLADLGGPGGGTAAFTGYLRSLGDTVSRLDAEEPELNRDPPGD
ERDTTTPHAIALVLQQLVLGNALPPDKRALLTDWMARNTTGAKRIRAGFP
ADWKVIDKTGTGDYGRANDIAVVWSPTGVPYVVAVMSDRAGGGYDAEPRE
ALLAEAATCVAGVLA
3D structure
PDB6b6d Enzyme intermediates captured "on the fly" by mix-and-inject serial crystallography.
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S70 K73 S128 E168 K236 T239
Catalytic site (residue number reindexed from 1) S42 K45 S100 E140 K208 T211
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FZS A C69 S70 I103 S128 P169 N172 T237 G238 T239 G240 C41 S42 I75 S100 P141 N144 T209 G210 T211 G212
BS02 9F2 A S70 I103 S128 P169 T237 G238 T239 G240 S42 I75 S100 P141 T209 G210 T211 G212
Gene Ontology
Molecular Function
GO:0008800 beta-lactamase activity
GO:0016787 hydrolase activity
Biological Process
GO:0017001 antibiotic catabolic process
GO:0030655 beta-lactam antibiotic catabolic process
GO:0046677 response to antibiotic
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0042597 periplasmic space

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6b6d, PDBe:6b6d, PDBj:6b6d
PDBsum6b6d
PubMed29848358
UniProtP9WKD3|BLAC_MYCTU Beta-lactamase (Gene Name=blaC)

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