Structure of PDB 6b67 Chain A

Receptor sequence
>6b67A (length=296) Species: 9606 (Homo sapiens) [Search protein sequence]
GAFLDKPKMEKHNAQGQGNGLRYGLSSMQGWRVEMEDAHTAVIGLPSGLE
SWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDFKGSAGAPSVENVKNGI
RTGFLEIDEHMRVMSEKKHGADRSGSTAVGVLISPQHTYFINCGESRGLL
CRNRKVHFFTQDHKPSNPLEKERIQNAGGSVMIQRVNGSLAVSRALGDFD
YKCVHGKGPTEQLVSPEPEVHDIERSEEDDQFIILACDGIWDVMGNEELC
DFVRSRLEVTDDLEKVCNEVVDTCLYKGSRDNMSVILICFPNAPKV
3D structure
PDB6b67 A trapped human PPM1A-phosphopeptide complex reveals structural features critical for regulation of PPM protein phosphatase activity.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.16: protein-serine/threonine phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A G2 A3 R33 H62 A63 R186 L191 A192 G1 A2 R32 H61 A62 R185 L190 A191
BS02 CA A D60 G61 D59 G60
BS03 CA A D60 D239 D282 D59 D238 D281
BS04 CA A D239 D243 D238 D242
Gene Ontology
Molecular Function
GO:0004722 protein serine/threonine phosphatase activity
GO:0043169 cation binding
Biological Process
GO:0006470 protein dephosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6b67, PDBe:6b67, PDBj:6b67
PDBsum6b67
PubMed29602904
UniProtP35813|PPM1A_HUMAN Protein phosphatase 1A (Gene Name=PPM1A)

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