Structure of PDB 6b5k Chain A

Receptor sequence
>6b5kA (length=277) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
MRGIILAGGSGTRLYPITMGISKQLLPVYDKPMIYYPLTTLMMAGIRDIQ
LITTPHDAPGFHRLLGDGAHLGVNISYATQDQPDGLAQAFVIGANHIGAD
SVALVLGDNIFYGPGLGTSLKRFQSISGGAIFAYWVANPSAYGVVEFLSL
EEKPKSNYAVPGLYFYDNDVIEIARGLKKSARGEYEITEVNQVYLNQGRL
AVEVLARGTAWLDTGTFDSLLDAADFVRTLERRQGLKVSIPEEVAWRMGW
IDDEQLVQRARALVKSGYGNYLLELLE
3D structure
PDB6b5k The structure of glucose-1-phosphate thymidylyltransferase from Mycobacterium tuberculosis reveals the location of an essential magnesium ion in the RmlA-type enzymes.
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.24: glucose-1-phosphate thymidylyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TTP A L6 G8 G9 G11 T12 R13 K23 Q24 Q80 P83 G85 L86 G107 D108 L6 G8 G9 G11 T12 R13 K23 Q24 Q80 P83 G85 L86 G107 D108
BS02 MG A D108 D222 D108 D213
BS03 TYD A M43 Y112 G113 G115 L116 G117 T118 S119 V247 E252 M43 Y112 G113 G115 L116 G117 T118 S119 V238 E243
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0008879 glucose-1-phosphate thymidylyltransferase activity
GO:0016779 nucleotidyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006006 glucose metabolic process
GO:0009058 biosynthetic process
GO:0019305 dTDP-rhamnose biosynthetic process
GO:0045226 extracellular polysaccharide biosynthetic process
GO:0046075 dTTP metabolic process
Cellular Component
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

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Cellular Component
External links
PDB RCSB:6b5k, PDBe:6b5k, PDBj:6b5k
PDBsum6b5k
PubMed29076563
UniProtP9WH13|RMLA_MYCTU Glucose-1-phosphate thymidylyltransferase (Gene Name=rmlA)

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