Structure of PDB 6b4l Chain A

Receptor sequence
>6b4lA (length=150) Species: 9606 (Homo sapiens) [Search protein sequence]
SMDLYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGV
QRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISF
GAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFH
3D structure
PDB6b4l Structure-guided design of a series of MCL-1 inhibitors with high affinity and selectivity.
ChainA
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CJY A M231 V253 R263 L267 F270 M61 V83 R93 L97 F100 MOAD: Ki=0.34uM
PDBbind-CN: -logKd/Ki=6.47,Ki=0.34uM
BindingDB: Ki=7300nM
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:6b4l, PDBe:6b4l, PDBj:6b4l
PDBsum6b4l
PubMed25679114
UniProtQ07820|MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Gene Name=MCL1)

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