Structure of PDB 6b2p Chain A

Receptor sequence
>6b2pA (length=255) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
PSHLSDRYELGEILGFGGMSEVHLARDLRLHRDVAVKVLRADLARDPSFY
LRFRREAQNAAALNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDI
VHTEGPMTPKRAIEVIADACQALNFSHQNGIIHRDVKPANIMISATNAVK
VMDFGTAQYLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTGDSPVS
VAYQHVREDPIPPSARHEGLSADLDAVVLKALAKNPENRYQTAAEMRADL
VRVHN
3D structure
PDB6b2p Mtb PKNA/PKNB Dual Inhibition Provides Selectivity Advantages for Inhibitor Design To Minimize Host Kinase Interactions.
ChainA
Resolution3.01 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D138 K140 N143 D156 T179
Catalytic site (residue number reindexed from 1) D135 K137 N140 D153 T156
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CJJ A G18 V25 A38 M92 E93 Y94 V95 G97 M145 M155 G15 V22 A35 M89 E90 Y91 V92 G94 M142 M152 PDBbind-CN: -logKd/Ki=8.89,Ki<1.3nM
BindingDB: Ki=<1.3nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6b2p, PDBe:6b2p, PDBj:6b2p
PDBsum6b2p
PubMed29259738
UniProtP9WI81|PKNB_MYCTU Serine/threonine-protein kinase PknB (Gene Name=pknB)

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